The question "How many people are in Twice?" is ambiguous and requires clarification. "Twice" could refer to:
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The South Korean pop group TWICE: This is the most likely interpretation. TWICE currently has nine members.
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A doubled quantity of people: If "Twice" refers to a doubling of a previously mentioned group of people, the answer depends entirely on the size of the original group. For example, "twice as many people as are in this room" requires knowing how many people are in the room.
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A metaphorical use: The word "twice" could be used figuratively, and in that case, there's no numerical answer.
To provide a definitive answer, please clarify what "Twice" refers to. If you're asking about the K-Pop group, the answer is nine.